Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition

Iron and Ferritin Modulate MHC Class I Expression and NK Cell Recognition

The ability of pathogens to sequester iron from their host cells and proteins affects their virulence. Moreover, iron is required for various innate host defense mechanisms as well as for acquired immune responses. Therefore, intracellular iron concentration may influence the interplay between patho...

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Bibliographic Details
Main Authors: Rosa Sottile, Giorgia Federico, Cinzia Garofalo, Rossana Tallerico, Maria Concetta Faniello, Barbara Quaresima, Costanza Maria Cristiani, Maddalena Di Sanzo, Gianni Cuda, Valeria Ventura, Arnika Kathleen Wagner, Gianluca Contrò, Nicola Perrotti, Elio Gulletta, Soldano Ferrone, Klas Kärre, Francesco Saverio Costanzo, Francesca Carlomagno, Ennio Carbone
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
MHC-I
NK cells
iron
IFNγ
STAT1
HLA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00224/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00224/full

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