Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation

Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation

5-Aminolevulinic acid (5-ALA) has been approved for clinical photodynamic therapy (PDT) due to its negligible photosensitive toxicity. However, the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor cells. Inspired by the...

Full description

Bibliographic Details
Main Authors: Airong Li, Chenglin Liang, Lihua Xu, Yiyang Wang, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
5-Aminolevulinic acid
Biotransformation interference
Iron ion regulation
DNA repair inhibition
ALKBH2
Membrane fusion liposomes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000903

Internet

http://www.sciencedirect.com/science/article/pii/S2211383521000903

Similar Items