Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGFβ3

Loss of muscleblind-like 1 promotes invasive mesenchyme formation in endocardial cushions by stimulating autocrine TGFβ3

<p>Abstract</p> <p>Background</p> <p>Valvulogenesis and septation in the developing heart depend on the formation and remodeling of endocardial cushions in the atrioventricular canal (AVC) and outflow tract (OFT). These cushions are invaded by a subpopulation of endocar...

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Bibliographic Details
Main Authors: LeMasters Kathryn E, Blech-Hermoni Yotam, Stillwagon Samantha J, Vajda Natalie A, Ladd Andrea N
Format: Article
Language:English
Published: BMC 2012-08-01
Series:BMC Developmental Biology
Subjects:
Muscleblind-like 1
Alternative splicing
TGFβ
Endocardial cushions
Epithelial-mesenchymal transition
Cell invasion
Online Access:http://www.biomedcentral.com/1471-213X/12/22

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http://www.biomedcentral.com/1471-213X/12/22

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