Canonical Wnt Signaling Protects Hippocampal Neurons from Aβ Oligomers: Role of Non-Canonical Wnt-5a/Ca2+ in Mitochondrial Dynamics

Canonical Wnt Signaling Protects Hippocampal Neurons from Aβ Oligomers: Role of Non-Canonical Wnt-5a/Ca2+ in Mitochondrial Dynamics

Alzheimer´s disease (AD) is the most common type of age-related dementia. The disease is characterized by a progressive loss of cognitive abilities, severe neurodegeneration, synaptic loss and mitochondrial dysfunction. The Wnt signaling pathway participates in the development of the centra...

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Bibliographic Details
Main Authors: Carmen eSilva-Alvarez, Macarena eArrazola, Juan A Godoy, Daniela eOrdenes, Nibaldo C. Inestrosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Mitochondria
hippocampal neurons
Aβ oligomers
Wnt-5a signaling
Wnt/Ca2+
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00097/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00097/full

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