Colorectal mucus binds DC-SIGN and inhibits HIV-1 trans-infection of CD4+ T-lymphocytes.

Colorectal mucus binds DC-SIGN and inhibits HIV-1 trans-infection of CD4+ T-lymphocytes.

Bodily secretions, including breast milk and semen, contain factors that modulate HIV-1 infection. Since anal intercourse caries one of the highest risks for HIV-1 transmission, our aim was to determine whether colorectal mucus (CM) also contains factors interfering with HIV-1 infection and replicat...

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Bibliographic Details
Main Authors: Martijn J Stax, Emily E I M Mouser, Thijs van Montfort, Rogier W Sanders, Henry J C de Vries, Henk L Dekker, Carolina Herrera, Dave Speijer, Georgios Pollakis, William A Paxton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368515?pdf=render

Internet

http://europepmc.org/articles/PMC4368515?pdf=render

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