Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21

Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21

Background: Natural Killer (NK) cell-based immunotherapy used to treat cancer requires the adoptive transfer of a large number of activated NK cells. Here, we report a new effective method to expand human NK cells ex vivo using K562 cells genetically engineered (GE) to express OX40 ligand (K562-OX40...

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Bibliographic Details
Main Authors: SoonHo Kweon, Minh-Trang Thi Phan, Sejong Chun, HongBi Yu, Jinho Kim, Seokho Kim, Jaemin Lee, Alaa Kassim Ali, Seung-Hwan Lee, Sang-Ki Kim, Junsang Doh, Duck Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
expansion
IL-21
K562
OX40 ligand
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00879/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00879/full

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