Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway

Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway

Sirtuins are NAD-dependent protein deacetylases that were shown to have protective effects against different age-related diseases. SIRT2 is a strong deacetylase that is highly expressed in brain. It has been associated with neurodegenerative diseases. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridi...

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Bibliographic Details
Main Authors: Lei eLiu, Anirudh eArun, Lakia eEllis, Carina ePeritore, Gizem eDonmez
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Apoptosis
SIRT2
Parkinson’s disease
SIRTUIN
MPTP
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00184/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00184/full

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