Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I<sub>2</sub>-Imidazoline Receptor Ligand MCR5

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I<sub>2</sub>-Imidazoline Receptor Ligand MCR5

Behavioural and psychological symptoms of dementia (BPSD), including fear-anxiety- and depressive-like behaviour, are present in Alzheimer’s disease (AD), together with memory decline. I<sub>2</sub>-imidazoline receptors (I<sub>2</sub>-IRs) have been associated with neuropsyc...

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Bibliographic Details
Main Authors: Foteini Vasilopoulou, Andrea Bagan, Sergio Rodriguez-Arevalo, Carmen Escolano, Christian Griñán-Ferré, Mercè Pallàs
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
I<sub>2</sub>-imidazoline receptors
Behavioural and psychological symptoms of dementia (BPSD)
brain-derived neurotrophic factor (BDNF)
neuroinflammation
age
Online Access:https://www.mdpi.com/1999-4923/12/5/475

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https://www.mdpi.com/1999-4923/12/5/475

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