Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.

Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.

H3K9 trimethylation (H3K9me3) and binding of PcG repressor complex-1 (PRC1) may play crucial roles in the epigenetic silencing of the p16 gene. However, the mechanism of the initiation of this trimethylation is unknown.In the present study, we found that upregulating the expression of PRC1 component...

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Bibliographic Details
Main Authors: Qiang Li, Xiuhong Wang, Zheming Lu, Baozhen Zhang, Zhenpo Guan, Zhaojun Liu, Qiming Zhong, Liankun Gu, Jing Zhou, Budong Zhu, Jiafu Ji, Dajun Deng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2966406?pdf=render

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http://europepmc.org/articles/PMC2966406?pdf=render

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