Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we assessed the effects of attaching sugars to N-4 o...

Full description

Bibliographic Details
Main Authors: Yuet Wu, Silvia Parapini, Ian D. Williams, Paola Misiano, Ho Ning Wong, Donatella Taramelli, Nicoletta Basilico, Richard K. Haynes
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
artemisinins
artemisone
piperazine
N-glycosides
antimalarial activities
anti-tumour activities
Online Access:http://www.mdpi.com/1420-3049/23/7/1713

Internet

http://www.mdpi.com/1420-3049/23/7/1713

Similar Items