Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance.

Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of supraspinal side effects. However, repeated neuraxial ad...

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Bibliographic Details
Main Authors: Wen-Jinn Liaw, Cheng-Ming Tsao, Go-Shine Huang, Chin-Chen Wu, Shung-Tai Ho, Jhi-Joung Wang, Yuan-Xiang Tao, Hao-Ai Shui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3879267?pdf=render