YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity

YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity

Ubiquitination, a fundamental post-translational modification of intracellular proteins, is enzymatically reversed by deubiquitinase enzymes (deubiquitinases). >90 deubiquitinases have been identified. One of these enzymes, YOD1, possesses deubiquitinase activity and is similar to ovarian tumor d...

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Bibliographic Details
Main Authors: Kunikazu Tanji, Fumiaki Mori, Yasuo Miki, Jun Utsumi, Hidenao Sasaki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Cytotoxicity
Deubiquitinase
Huntington disease
Lysine residue
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300068

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http://www.sciencedirect.com/science/article/pii/S0969996118300068

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