Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice

Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice

Epidemiological and experimental data implicate maternal–fetal infection and an associated increase in circulating cytokines in the etiology of cerebral palsy. We have previously shown that pretreatment of newborn mice with systemic interleukin-1-beta exacerbates ibotenate-induced excitotoxic brain...

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Bibliographic Details
Main Authors: Géraldine Favrais, Leslie Schwendimann, Pierre Gressens, Vincent Lelièvre
Format: Article
Language:English
Published: Elsevier 2007-03-01
Series:Neurobiology of Disease
Subjects:
Cerebral palsy
Pro-inflammatory cytokine
Excitotoxicity
Ibotenate
Nimesulide
Indomethacin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002841

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http://www.sciencedirect.com/science/article/pii/S0969996106002841

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