The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia

The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia

TRAF1 is a pro-survival adaptor molecule in TNFR superfamily (TNFRSF) signaling. TRAF1 is overexpressed in many B cell cancers including refractory chronic lymphocytic leukemia (CLL). Little has been done to assess the role of TRAF1 in human cancer. Here we show that the protein kinase C related kin...

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Bibliographic Details
Main Authors: Maria I. Edilova, Jaclyn C. Law, Safoura Zangiabadi, Kenneth Ting, Achire N. Mbanwi, Andrea Arruda, David Uehling, Methvin Isaac, Michael Prakesch, Rima Al-awar, Mark D. Minden, Ali A. Abdul-Sater, Tania H. Watts
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
chronic lymphocytic leukemia
tnfr-associated factors (trafs)
protein kinase n1
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1943234

Internet

http://dx.doi.org/10.1080/2162402X.2021.1943234

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