Pharmacokinetic and Safety Evaluation of Various Oral Doses of a Novel 1:20 THC:CBD Cannabis Herbal Extract in Dogs

Pharmacokinetic and Safety Evaluation of Various Oral Doses of a Novel 1:20 THC:CBD Cannabis Herbal Extract in Dogs

Objective: To determine the pharmacokinetics (PK) and safety of various oral doses of a Cannabis herbal extract (CHE) containing a 1:20 ratio of Δ9-tetrahydrocannabinol (THC):cannabidiol (CBD) in 13 healthy Beagle-cross dogs.Methods: Single-dose PK was assessed after oral administration of CHE at lo...

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Bibliographic Details
Main Authors: Alan Chicoine, Kate Illing, Stephanie Vuong, K. Romany Pinto, Jane Alcorn, Kevin Cosford
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Veterinary Science
Subjects:
cannabinoid
cannabidiol (CBD)
tetrahydrocannabinol (THC)
cannabichromene (CBC)
nonlinear pharmacokinetics
hyperesthesia
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.583404/full

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https://www.frontiersin.org/article/10.3389/fvets.2020.583404/full

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