A single Gal4-like transcription factor activates the Crabtree effect in Komagataella phaffii

Aerobic ethanol production, a phenomenon referred as Crabtree effect, allows yeast to outcompete other microorganisms in sugar rich environments. Here, the authors show that overexpression of a Gal4-like transcription factor can transform Komagataella phaffii from Crabtree effect negative to positiv...

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Bibliographic Details
Main Authors: Özge Ata, Corinna Rebnegger, Nadine E. Tatto, Minoska Valli, Teresa Mairinger, Stephan Hann, Matthias G. Steiger, Pınar Çalık, Diethard Mattanovich
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07430-4