Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms

Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and β-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms

Combining antibiotics with resistance reversing agents is a key strategy to overcome bacterial resistance. Upon screening antimicrobial activities of plants used in traditional medicine, we found that a leaf dichloromethane extract from the shea butter tree (Vitellaria paradoxa) had antimicrobial ac...

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Bibliographic Details
Main Authors: Lucy Catteau, Nathalie T. Reichmann, Joshua Olson, Mariana G. Pinho, Victor Nizet, Françoise Van Bambeke, Joëlle Quetin-Leclercq
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
Vitellaria paradoxa
ursolic acid
oleanolic acid
triterpenic acid
MRSA
β-lactamases
PBP2
skin infection
Online Access:https://www.mdpi.com/1420-3049/22/12/2245

Internet

https://www.mdpi.com/1420-3049/22/12/2245

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