Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

Abstract Background Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could help identify therapies to eliminate these cells. Si...

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Bibliographic Details
Main Authors: Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter, Angie Rizzino
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Cancer
Subjects:
SOX2
Prostate cancer
Pancreatic cancer
Medulloblastoma
Neuroblastoma
Online Access:http://link.springer.com/article/10.1186/s12885-020-07370-7

Internet

http://link.springer.com/article/10.1186/s12885-020-07370-7

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