Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia

Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia

NK cells can exert remarkable graft-versus-leukemia (GvL) effect in HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Here, we dissected the NK-cell repertoire of 80 pediatric acute leukemia patients previously reported to have an excellent clinical outcome after αβT/B-deplete...

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Bibliographic Details
Main Authors: Raffaella Meazza, Michela Falco, Fabrizio Loiacono, Paolo Canevali, Mariella Della Della Chiesa, Alice Bertaina, Daria Pagliara, Pietro Merli, Valentina Indio, Federica Galaverna, Mattia Algeri, Francesca Moretta, Natalia Colomar-Carando, Letizia Muccio, Simona Sivori, Andrea Pession, Maria Cristina Mingari, Lorenzo Moretta, Alessandro Moretta, Franco Locatelli, Daniela Pende
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
NK cells
haploidentical hematopoietic stem cell transplantation (HSCT)
killer Ig-like receptors (KIR)
NK alloreactivity
pediatric acute leukemia
human cytomegalovirus (HCMV)
Online Access:https://www.mdpi.com/2072-6694/12/8/2187

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https://www.mdpi.com/2072-6694/12/8/2187

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