A High-Throughput Method for Characterizing Novel Chimeric Antigen Receptors in Jurkat Cells

A High-Throughput Method for Characterizing Novel Chimeric Antigen Receptors in Jurkat Cells

Chimeric antigen receptor (CAR) development involves extensive empirical characterization of antigen-binding domain (ABD)/CAR constructs for clinical suitability. Here, we present a cost-efficient and rapid method for evaluating CARs in human Jurkat T cells. Using a modular CAR plasmid, a highly eff...

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Bibliographic Details
Main Authors: Darin Bloemberg, Tina Nguyen, Susanne MacLean, Ahmed Zafer, Christine Gadoury, Komal Gurnani, Anindita Chattopadhyay, Josée Ash, Julie Lippens, Doreen Harcus, Martine Pagé, Annie Fortin, Robert A. Pon, Rénald Gilbert, Anne Marcil, Risini D. Weeratna, Scott McComb
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300231

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http://www.sciencedirect.com/science/article/pii/S2329050120300231

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