Signaling properties of the human chemokine receptors CXCR4 and CXCR7 by cellular electric impedance measurements.

The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors involved in various diseases including human cancer. As such, they have become important targets for therapeutic intervention. Cell-based receptor assays, able to detect agents that modulate receptor activity, are of key...

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Bibliographic Details
Main Authors: Jordi Doijen, Tom Van Loy, Wouter De Haes, Bart Landuyt, Walter Luyten, Liliane Schoofs, Dominique Schols
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5612718?pdf=render