YB-1 Interferes with TNFα–TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling

YB-1 Interferes with TNFα–TNFR Binding and Modulates Progranulin-Mediated Inhibition of TNFα Signaling

Inflammation and an influx of macrophages are common elements in many diseases. Among pro-inflammatory cytokines, tumor necrosis factor α (TNFα) plays a central role by amplifying the cytokine network. Progranulin (PGRN) is a growth factor that binds to TNF receptors and interferes with TNFα-mediate...

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Bibliographic Details
Main Authors: Christopher L. Hessman, Josephine Hildebrandt, Aneri Shah, Sabine Brandt, Antonia Bock, Björn C. Frye, Ute Raffetseder, Robert Geffers, Monika C. Brunner-Weinzierl, Berend Isermann, Peter R. Mertens, Jonathan A. Lindquist
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
Y-box binding protein-1 (YB-1)
DNA binding protein-B (DbpB)
progranulin
tumor necrosis factor alpha (TNFα)
inflammation
immune modulation
Online Access:https://www.mdpi.com/1422-0067/21/19/7076

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https://www.mdpi.com/1422-0067/21/19/7076

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