Adenovirus-Mediated Inducible Expression of a PD-L1 Blocking Antibody in Combination with Macrophage Depletion Improves Survival in a Mouse Model of Peritoneal Carcinomatosis

Adenovirus-Mediated Inducible Expression of a PD-L1 Blocking Antibody in Combination with Macrophage Depletion Improves Survival in a Mouse Model of Peritoneal Carcinomatosis

Immune checkpoint inhibitors (ICIs) have demonstrated remarkable efficacy in a growing number of malignancies. However, overcoming primary or secondary resistances is difficult due to pharmacokinetics issues and side effects associated with high systemic exposure. Local or regional expression of mon...

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Bibliographic Details
Main Authors: Maria Buñuales, Maria Cristina Ballesteros-Briones, Manuela Gonzalez-Aparicio, Sandra Hervas-Stubbs, Eva Martisova, Uxua Mancheño, Ana Ricobaraza, Sara Lumbreras, Cristian Smerdou, Ruben Hernandez-Alcoceba
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
PD-L1
immune checkpoint inhibitor
adenovirus
high-capacity adenoviral vector
colorectal cancer
peritoneal carcinomatosis
Online Access:https://www.mdpi.com/1422-0067/22/8/4176

Internet

https://www.mdpi.com/1422-0067/22/8/4176

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