Oxidative and Non-Oxidative Antimicrobial Activities of the Granzymes

Oxidative and Non-Oxidative Antimicrobial Activities of the Granzymes

Cell-mediated cytotoxicity is an essential immune defense mechanism to fight against viral, bacterial or parasitic infections. Upon recognition of an infected target cell, killer lymphocytes form an immunological synapse to release the content of their cytotoxic granules. Cytotoxic granules of human...

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Bibliographic Details
Main Authors: Marilyne Lavergne, Maria Andrea Hernández-Castañeda, Pierre-Yves Mantel, Denis Martinvalet, Michael Walch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
granzymes
ROS - reactive oxygen species
caspases
antimicrobial defense
apoptosis
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.750512/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.750512/full

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