Phosphate regulator PhoP directly and indirectly controls transcription of the erythromycin biosynthesis genes in Saccharopolyspora erythraea

Phosphate regulator PhoP directly and indirectly controls transcription of the erythromycin biosynthesis genes in Saccharopolyspora erythraea

Abstract Background The choice of phosphate/nitrogen source and their concentrations have been shown to have great influences on antibiotic production. However, the underlying mechanisms responsible for this remain poorly understood. Results We show that nutrient-sensing regulator PhoP (phosphate re...

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Bibliographic Details
Main Authors: Ya Xu, Di You, Li-li Yao, Xiaohe Chu, Bang-Ce Ye
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Microbial Cell Factories
Subjects:
Erythromycin biosynthesis
Antibiotics
Phosphate metabolism
PhoP regulator
Transcriptional regulation
Online Access:http://link.springer.com/article/10.1186/s12934-019-1258-y

Internet

http://link.springer.com/article/10.1186/s12934-019-1258-y

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