Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition.

Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition.

Viruses have long been implicated in the pathogenesis of autoimmunity, yet their contribution remains circumstantial partly due to the lack of well-documented information on infections prior to autoimmune disease onset. Here, we used the lymphocytic choriomeningitis virus (LCMV) as a model to mechan...

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Bibliographic Details
Main Authors: Rosana Gonzalez-Quintial, Anthony Nguyen, Dwight H Kono, Michael B A Oldstone, Argyrios N Theofilopoulos, Roberto Baccala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6130858?pdf=render

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http://europepmc.org/articles/PMC6130858?pdf=render

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