Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway

Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway

Hepatic stellate cell (HSC) activation is responsible for hepatic fibrogenesis and is associated with an overexpression of transcription 3 (STAT3). Luteolin, a common dietary flavonoid with potent anti-inflammatory properties, has previously demonstrated antifibrogenic properties in HSCs but the mec...

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Bibliographic Details
Main Authors: Claire B. Cummins, Xiaofu Wang, Omar Nunez Lopez, Gabriel Graham, Hong-Yan Tie, Jia Zhou, Ravi S. Radhakrishnan
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
hepatic fibrosis
hepatic stellate cells
luteolin
STAT3
Online Access:http://www.mdpi.com/1422-0067/19/6/1567

Internet

http://www.mdpi.com/1422-0067/19/6/1567

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