Comparing the renoprotective effects of BM-MSCs versus BM-MSC-exosomes, when combined with an anti-fibrotic drug, in hypertensive mice

Comparing the renoprotective effects of BM-MSCs versus BM-MSC-exosomes, when combined with an anti-fibrotic drug, in hypertensive mice

Fibrosis, a hallmark of chronic kidney disease (CKD), impairs the viability of human bone marrow derived-mesenchymal stromal cells (BM-MSCs) post-transplantation. To address this, we demonstrated that combining BM-MSCs with the anti-fibrotic drug, serelaxin (RLX), enhanced BM-MSC-induced renoprotect...

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Bibliographic Details
Main Authors: Yifang Li, Amlan Chakraborty, Brad R.S. Broughton, Dorota Ferens, Robert E. Widdop, Sharon D. Ricardo, Chrishan S. Samuel
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hypertensive CKD
Fibrosis
Mesenchymal stem cells
Exosomes
Relaxin
Combination therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221010404

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http://www.sciencedirect.com/science/article/pii/S0753332221010404

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