The “false-positive” conundrum in the NTP 2-year rodent cancer study database
In 1990, Ames and Gold described a conundrum of “too many carcinogens” among chemicals tested in rodent bioassays. Their proposed nongenotoxic carcinogenic mechanism was amplification of the background mutation rate via cytotoxicity induced by high doses of the test chemicals, thereby leading to inc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-05-01
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| Series: | Toxicology Research and Application |
| Online Access: | https://doi.org/10.1177/2397847318772839 |