Population Pharmacokinetics of Vincristine Related to Infusion Duration and Peripheral Neuropathy in Pediatric Oncology Patients

Population Pharmacokinetics of Vincristine Related to Infusion Duration and Peripheral Neuropathy in Pediatric Oncology Patients

Vincristine (VCR) is frequently used in pediatric oncology and can be administered intravenously through push injections or 1 h infusions. The effects of administration duration on population pharmacokinetics (PK) are unknown. We described PK differences related to administration duration and the re...

Full description

Bibliographic Details
Main Authors: Mirjam Esther van de Velde, John Carl. Panetta, Abraham J. Wilhelm, Marleen H. van den Berg, Inge M. van der Sluis, Cor van den Bos, Floor C.H. Abbink, Marry M. van den Heuvel-Eibrink, Heidi Segers, Christophe Chantrain, Jutte van der Werff Ten Bosch, Leen Willems, William E. Evans, Gertjan L. Kaspers
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
neurotoxicity
exposure
children
cancer
vincristine
toxicity
Online Access:https://www.mdpi.com/2072-6694/12/7/1789

Internet

https://www.mdpi.com/2072-6694/12/7/1789

Similar Items