Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice[S]

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice[S]

Besides bulk amounts of SM, mammalian cells produce small quantities of the SM analog ceramide phosphoethanolamine (CPE). Little is known about the biological role of CPE or enzymes responsible for CPE production. Heterologous expression studies revealed that SM synthase (SMS)2 is a bifunctional enz...

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Bibliographic Details
Main Authors: Andreas Bickert, Christina Ginkel, Matthijs Kol, Katharina vom Dorp, Holger Jastrow, Joachim Degen, René L. Jacobs, Dennis E. Vance, Elke Winterhager, Xian-Cheng Jiang, Peter Dörmann, Pentti Somerharju, Joost C.M. Holthuis, Klaus Willecke
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Lipid Research
Subjects:
brain lipids
enzyme inactivation
genetics
mass spectrometry
sterile α motif domain-containing protein 8
sphingomyelin synthase-related protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355644

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http://www.sciencedirect.com/science/article/pii/S0022227520355644

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