An alternative synthesis of (+) - propranolol and (+) – atenolol
Herein, a simple synthesis pathway of beta-blockers starting from allyl amine ispresented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol.
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| Format: | Article |
| Language: | English |
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Maejo University
2012-10-01
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| Series: | Maejo International Journal of Science and Technology |
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| Online Access: | http://www.mijst.mju.ac.th/vol6/372-378.pdf |