Varespladib Inhibits the Phospholipase A<sub>2</sub> and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Varespladib Inhibits the Phospholipase A<sub>2</sub> and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

Phospholipase A<sub>2</sub> (PLA<sub>2</sub>) enzymes are important toxins found in many snake venoms, and they can exhibit a variety of toxic activities including causing hemolysis and/or anticoagulation. In this study, the inhibiting effects of the small molecule PLA<sub...

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Bibliographic Details
Main Authors: Chunfang Xie, Laura-Oana Albulescu, Kristina B. M. Still, Julien Slagboom, Yumei Zhao, Zhengjin Jiang, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomedicines
Subjects:
varespladib
nanofractionation
PLA<sub>2</sub> activity
coagulopathic toxicity
neutralization
Online Access:https://www.mdpi.com/2227-9059/8/6/165

Internet

https://www.mdpi.com/2227-9059/8/6/165

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