Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP<sup>+</sup> Neurotoxicity

Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP<sup>+</sup> Neurotoxicity

We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP<sup>+</sup>-lesioned rat. However, the detailed mechanisms how microglia-...

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Bibliographic Details
Main Authors: Jeong Yeob Baek, Jae Yeong Jeong, Kyoung In Kim, So-Yoon Won, Young Cheul Chung, Jin Han Nam, Eun Ju Cho, Tae-Beom Ahn, Eugene Bok, Won-Ho Shin, Byung Kwan Jin
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
Microglia
Ciliary neurotrophic factor
Ciliary neurotrophic factor receptor
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/19/11/3543

Internet

https://www.mdpi.com/1422-0067/19/11/3543

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