Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Enable a Stable Non-Spilling Loading of T Cells and Their Magnetic Accumulation

Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles Enable a Stable Non-Spilling Loading of T Cells and Their Magnetic Accumulation

T cell infiltration into a tumor is associated with a good clinical prognosis of the patient and adoptive T cell therapy can increase anti-tumor immune responses. However, immune cells are often excluded from tumor infiltration and can lack activation due to the immune-suppressive tumor microenviron...

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Bibliographic Details
Main Authors: Philipp Boosz, Felix Pfister, Rene Stein, Bernhard Friedrich, Lars Fester, Julia Band, Marina Mühlberger, Eveline Schreiber, Stefan Lyer, Diana Dudziak, Christoph Alexiou, Christina Janko
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
nanomedicine
superparamagnetic iron oxide nanoparticles (SPIONs)
adoptive T cell transfer
immune therapy
targeted transport
solid tumor
Online Access:https://www.mdpi.com/2072-6694/13/16/4143

Internet

https://www.mdpi.com/2072-6694/13/16/4143

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