Altered Differentiation Potential of Gaucherâs Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation

Altered Differentiation Potential of Gaucherâs Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation

Summary: Gaucherâs disease (GD) is an autosomal recessive disorder caused by mutations in the GBA1 gene, which encodes acid β-glucocerebrosidase (GCase). Severe GBA1 mutations cause neuropathology that manifests soon after birth, suggesting that GCase deficiency interferes with neuronal development...

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Bibliographic Details
Main Authors: Ola Awad, Leelamma M. Panicker, Rania M. Deranieh, Manasa P. Srikanth, Robert A. Brown, Antanina Voit, Tejasvi Peesay, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117304848

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http://www.sciencedirect.com/science/article/pii/S2213671117304848

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