Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

Abstract Tissue resident memory T cells (TRM) have been identified in various tissues, however human liver TRM to date remain unidentified. TRM can be recognized by CD69 and/or CD103 expression and may play a role in the pathology of chronic hepatitis B (CHB) and hepatitis C virus infection (CHC). L...

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Bibliographic Details
Main Authors: Femke Stelma, Annikki de Niet, Marjan J. Sinnige, Karel A. van Dort, Klaas P. J. M. van Gisbergen, Joanne Verheij, Ester M. M. van Leeuwen, Neeltje A. Kootstra, Hendrik W. Reesink
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06352-3

Internet

https://doi.org/10.1038/s41598-017-06352-3

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