Brain-Derived Neurotrophic Factor Secreting Human Mesenchymal Stem Cells Improve Outcomes in Rett Syndrome Mouse Models

Brain-Derived Neurotrophic Factor Secreting Human Mesenchymal Stem Cells Improve Outcomes in Rett Syndrome Mouse Models

Rett syndrome (RTT) is a severe X-linked dominant neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene; MeCP2 regulates the expression of brain-derived neurotrophic factor (BDNF) and increasing BDNF levels ameliorates RTT symptoms. However, the clinical ap...

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Bibliographic Details
Main Authors: Hyo Jeong Kim, Delger Bayarsaikhan, Jaesuk Lee, Govigerel Bayarsaikhan, Bonghee Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Neuroscience
Subjects:
Rett syndrome
MECP2
brain-derived neurotrophic factor
CRISPR-Cas system
transplantation
mesenchymal stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.725398/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.725398/full

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