Effects of ω3- and ω6-Polyunsaturated Fatty Acids on RANKL-Induced Osteoclast Differentiation of RAW264.7 Cells: A Comparative in Vitro Study

Effects of ω3- and ω6-Polyunsaturated Fatty Acids on RANKL-Induced Osteoclast Differentiation of RAW264.7 Cells: A Comparative in Vitro Study

Polyunsaturated fatty acids (PUFAs) have been reported to have an anabolic effect on bone in vivo, but comparative studies to identify inhibitors of osteoclast formation amongst ω3- and ω6-PUFAs are still lacking. Here we assessed the effects of the ω3-PUFAs, eicosapentaenoic acid (EPA) and docosah...

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Bibliographic Details
Main Authors: Jan C. A. Boeyens, Vishwa Deepak, Wei-Hang Chua, Marlena C. Kruger, Annie M. Joubert, Magdalena Coetzee
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Nutrients
Subjects:
osteoclasts
polyunsaturated fatty acids
bone resorption
arachidonic acid
gamma-linolenic acid
eicosapentaenoic acid
docosahexaenoic acid
RAW264.7 macrophages
Online Access:http://www.mdpi.com/2072-6643/6/7/2584

Internet

http://www.mdpi.com/2072-6643/6/7/2584

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