Location of the CD8 T cell epitope within the antigenic precursor determines immunogenicity and protection against the Toxoplasma gondii parasite.

CD8 T cells protect the host from disease caused by intracellular pathogens, such as the Toxoplasma gondii (T. gondii) protozoan parasite. Despite the complexity of the T. gondii proteome, CD8 T cell responses are restricted to only a small number of peptide epitopes derived from a limited set of an...

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Bibliographic Details
Main Authors: Virginie Feliu, Virginie Vasseur, Harshita S Grover, H Hamlet Chu, Mark J Brown, Jeremy Wang, Jon P Boyle, Ellen A Robey, Nilabh Shastri, Nicolas Blanchard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3688528?pdf=render