Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials.

Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials.

The ongoing Antibody Mediated Prevention (AMP) trials will uncover whether passive infusion of the broadly neutralizing antibody (bNAb) VRC01 can protect against HIV acquisition. Previous statistical simulations indicate these trials may be partially protective. In that case, it will be crucial to i...

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Bibliographic Details
Main Authors: Daniel B Reeves, Yunda Huang, Elizabeth R Duke, Bryan T Mayer, E Fabian Cardozo-Ojeda, Florencia A Boshier, David A Swan, Morgane Rolland, Merlin L Robb, John R Mascola, Myron S Cohen, Lawrence Corey, Peter B Gilbert, Joshua T Schiffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007626

Internet

https://doi.org/10.1371/journal.pcbi.1007626

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