Nidogen 1‐Enriched Extracellular Vesicles Facilitate Extrahepatic Metastasis of Liver Cancer by Activating Pulmonary Fibroblasts to Secrete Tumor Necrosis Factor Receptor 1

Nidogen 1‐Enriched Extracellular Vesicles Facilitate Extrahepatic Metastasis of Liver Cancer by Activating Pulmonary Fibroblasts to Secrete Tumor Necrosis Factor Receptor 1

Abstract In hepatocellular carcinoma (HCC) patients with extrahepatic metastasis, the lung is the most frequent site of metastasis. However, how the lung microenvironment favors disseminated cells remains unclear. Here, it is found that nidogen 1 (NID1) in metastatic HCC cell‐derived extracellular v...

Full description

Bibliographic Details
Main Authors: Xiaowen Mao, Sze Keong Tey, Cherlie Lot Sum Yeung, Ernest Man Lok Kwong, Yi Man Eva Fung, Clive Yik Sham Chung, Lung‐Yi Mak, Danny Ka Ho Wong, Man‐Fung Yuen, James Chung Man Ho, Herbert Pang, Maria Pik Wong, Carmen Oi‐Ning Leung, Terence Kin Wah Lee, Victor Ma, William Chi‐Shing Cho, Peihua Cao, Xiaoping Xu, Yi Gao, Judy Wai Ping Yam
Format: Article
Language:English
Published: Wiley 2020-11-01
Series:Advanced Science
Subjects:
extracellular vesicles
hepatocellular carcinoma
nidogen 1
pre‐metastatic niche
tumor necrosis factor receptor 1
Online Access:https://doi.org/10.1002/advs.202002157

Internet

https://doi.org/10.1002/advs.202002157

Similar Items