Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling

Distinctive epigenomic alterations in NF1-deficient cutaneous and plexiform neurofibromas drive differential MKK/p38 signaling

Abstract Benign peripheral nerve sheath tumors are the clinical hallmark of Neurofibromatosis Type 1. They account for substantial morbidity and mortality in NF1. Cutaneous (CNF) and plexiform neurofibromas (PNF) share nearly identical histology, but maintain different growth rates and risk of malig...

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Bibliographic Details
Main Authors: Jamie L. Grit, Benjamin K. Johnson, Patrick S. Dischinger, Curt J. Essenburg, Marie Adams, Stacy Campbell, Kai Pollard, Christine A. Pratilas, Tim J. Triche, Carrie R. Graveel, Matthew R. Steensma
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Epigenetics & Chromatin
Subjects:
Epigenome
Neurofibromatosis
Neurofibroma
Inflammation
RAS
Online Access:https://doi.org/10.1186/s13072-020-00380-6

Internet

https://doi.org/10.1186/s13072-020-00380-6

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