Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats.

OBJECTIVE: Erectile dysfunction (ED) is considered as an early sign of vascular disease due to its high prevalence in patients with cardiovascular risk factors. Endothelial and neural dysfunction involving nitric oxide (NO) are usually implicated in the pathophysiology of the diabetic ED, but the un...

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Bibliographic Details
Main Authors: Ana Sánchez, Cristina Contreras, María Pilar Martínez, Belén Climent, Sara Benedito, Albino García-Sacristán, Medardo Hernández, Dolores Prieto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3335073?pdf=render