Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a co...

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Bibliographic Details
Main Authors: Louise C. Rowntree, Heleen van den Heuvel, Jessica Sun, Lloyd J. D'Orsogna, Thi H. O. Nguyen, Frans H. J. Claas, Jamie Rossjohn, Tom C. Kotsimbos, Anthony W. Purcell, Nicole A. Mifsud
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
cross-reactivity
CMV
EBV
HIV-1
HLA
T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00248/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00248/full

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