The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest

The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest

Dendritic arbor architecture profoundly impacts neuronal connectivity and function, and aberrant dendritic morphology characterizes neuropsychiatric disorders. Here, we identify the adhesion-GPCR BAI1 as an important regulator of dendritic arborization. BAI1 loss from mouse or rat hippocampal neuron...

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Bibliographic Details
Main Authors: Joseph G Duman, Shalaka Mulherkar, Yen-Kuei Tu, Kelly C Erikson, Christopher P Tzeng, Vasilis C Mavratsas, Tammy Szu-Yu Ho, Kimberley F Tolias
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
branching
retraction
hippocampal cultures
Raichu
Long-Evans rats
RhoA-FLARE
Online Access:https://elifesciences.org/articles/47566

Internet

https://elifesciences.org/articles/47566

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