Disruption of PTPS Gene Causing Pale Body Color and Lethal Phenotype in the Silkworm, Bombyx mori

Disruption of PTPS Gene Causing Pale Body Color and Lethal Phenotype in the Silkworm, Bombyx mori

Phenylketonuria (PKU) is an inborn error of metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene or by defects in the tetrahydrobiopterin (BH4) synthesis pathway. Here, by positional cloning, we report that the 6-pyruvoyl-tetrahydropterin synthase (PTPS) gene, encoding a key en...

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Bibliographic Details
Main Authors: Xiaoling Tong, Pingfeng Liang, Songyuan Wu, Yuanhao Li, Liang Qiao, Hai Hu, Zhonghuai Xiang, Cheng Lu, Fangyin Dai
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
silkworm model
alc
PTPS
BH4
phenylketonuria
Online Access:http://www.mdpi.com/1422-0067/19/4/1024

Internet

http://www.mdpi.com/1422-0067/19/4/1024

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