Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

Objective: Functional investigation of novel gene/protein targets associated with adipocyte differentiation or function heavily relies on efficient and accessible tools to manipulate gene expression in adipocytes in vitro. Recent advances in gene-editing technologies such as CRISPR-Cas9 have not onl...

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Bibliographic Details
Main Authors: Morten Lundh, Kaja Pluciñska, Marie S. Isidor, Patricia S.S. Petersen, Brice Emanuelli
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
CRISPRa
siRNA
Adipogenesis
Adipocyte
Browning
Gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817303381

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http://www.sciencedirect.com/science/article/pii/S2212877817303381

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