Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells

Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells

Genetic changes in human pluripotent stem cells (hPSCs) gained during culture can confound experimental results and potentially jeopardize the outcome of clinical therapies. Particularly common changes in hPSCs are trisomies of chromosomes 1, 12, 17, and 20. Thus, hPSCs should be regularly screened...

Full description

Bibliographic Details
Main Authors: Duncan Baker, Adam J. Hirst, Paul J. Gokhale, Miguel A. Juarez, Steve Williams, Mark Wheeler, Kerry Bean, Thomas F. Allison, Harry D. Moore, Peter W. Andrews, Ivana Barbaric
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Stem Cell Reports
Subjects:
Human pluripotent stem cells
genetic changes
detection methods
sensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116302417

Internet

http://www.sciencedirect.com/science/article/pii/S2213671116302417

Similar Items