Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice

Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice

Fragile-X syndrome (FXS) is caused by the transcriptional repression of the Fmr1 gene resulting in loss of the Fragile-X mental retardation protein (FMRP). This leads to cognitive impairment in both male and female patients, however few studies have focused on the impact of FXS in females. Significa...

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Bibliographic Details
Main Authors: S.Y. Yau, C.A. Bostrom, J. Chiu, C.J. Fontaine, S. Sawchuk, A. Meconi, R.C. Wortman, E. Truesdell, A Truesdell, C Chiu, B.N. Hryciw, B.D Eadie, M. Ghilan, B.R Christie
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Fragile X syndrome
Females
Hippocampus
Learning and memory
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302297

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http://www.sciencedirect.com/science/article/pii/S0969996116302297

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